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MINE (chemotherapy)
MINE in the context of chemotherapy is an acronym for one of the chemotherapy regimens used for treatment of relapsed or refractory aggressive non-Hodgkin's lymphoma and Hodgkin lymphoma as well.
Today this regimen is often combined with monoclonal antibody rituximab. In this case the regimen is called R-MINE or MINE-R.
The ()-MINE regimen consists of:
# (R)ituximab - anti-CD20 monoclonal antibody that can kill both normal CD20-expressing B cells and malignant ones;
# (M)esna to prevent the development of hemorrhagic cystitis which may otherwise result from ifosfamide administration;
# (I)fosfamide - an alkylating antineoplastic agent from oxazafosforine group;
# (N)ovantrone - a synthetic antracycline analogue (antraquinone) that is able to intercalate DNA and thus prevent cell division (mitosis);
# (E)toposide - a topoisomerase inhibitor.〔(A phase II trial of mesna / ifosfamide, mitoxantrone and etoposide for refractory lymphomas )〕〔 (Results of a salvage treatment program for relapsing lymphoma: MINE consolidated with ESHAP. )〕
== Dosing regimen ==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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